CBD and the treatment of Cholangiocarcinoma. Why Patients are Seeking Medical Cannabis.

CBD and the treatment of Cholangiocarcinoma
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Cholangiocarcinoma, often known as bile duct cancer, is a rare type of cancer and usually begins in the bile ducts. It frequently affects older people and has gone outside the bile ducts by the time it is identified.  Bile ducts are narrow tubes that transport bile (a digestive fluid) from your liver and gallbladder to your small intestine. Most people are diagnosed with cholangiocarcinoma after the cancer has spread outside of their bile ducts. It is difficult to cure, and the prognosis (probability of recovery) is typically bad. A rising number of targeted medicines and clinical trials, however, are beginning to change that. Surgery, chemotherapy, or radiation therapy are commonly used in treatment. Can Cannabis products help to manage the symptoms?

What is the cause of cholangiocarcinoma?

Experts are unsure what causes cholangiocarcinoma. The risk factors indicate that persistent (long-term) inflammation in the bile ducts may have a role in the development of this cancer. Persistent damage, such as inflammation, can also cause DNA alterations, which can alter how particular cells grow, divide, and behave. These modifications are most likely not inherited, which implies that parents do not pass them on to their offspring. Changes are more likely to occur over a person’s lifetime.

What signs and symptoms indicate cholangiocarcinoma?

Symptoms of bile duct carcinoma include abdominal pain.

  • Dark Urine
  • Fever
  • Skin itch
  • Jaundice (yellowing of the skin and whites of the eyes).
  • Stool in a light colour.
  • Vomiting and nausea.
  • Unknown cause of weight reduction.

How can CBD help people with cholangiocarcinoma manage their symptoms?

The right dosage of CBD can help one to manage various symptoms of this cancer such as:

Itchiness: It can appear for a variety of reasons. CBD, as the label suggests, can stop itching in some cases and provide partial relief in others. It functions by interacting with the CB1 and CB2 receptors of the body’s endocannabinoid system. These receptors can be found in the skin, organs, and other regulatory systems, and they can even affect the brain via neurotransmitters. CBD can provide relief from skin issues such as itching, dryness, irritation, redness, and inflammation due to its ability to inhibit reactions within the immunological and nervous systems. CBD has the ability to alleviate these symptoms while also giving tools to assist the body’s systems in achieving homeostasis or equilibrium. As a result, CBD may be able to reduce the frequency or intensity of future itching episodes.

By reducing inflammation: One of the most important ways CBD affects the body is by reducing skin irritation. So, why is this important? Itching and inflammation are both reactions caused by the immune system guarding the body from what it regards as intruders or something that does not belong. However, the immune system can occasionally cause inflammation as a result of an autoimmune function, in which it is essentially fighting against itself. Psoriasis and rosacea are examples of autoimmune diseases. CBD can soothe the immune system by lowering inflammation and relieving the itching or discomfort associated with certain illnesses.

Is it safe to consume?

Although current research is limited, some experts believe CBD may help with a variety of symptoms associated with various diseases, such as nausea, discomfort, and anxiety. Most importantly, CBD does not produce the “high” that many people associate with marijuana. This is caused by tetrahydrocannabinol (THC), another cannabinoid found in the Cannabis sativa plant.

Does CBD help with nausea?

There has been little research into the use of CBD for nausea. The majority of the scientific material on CBD and nausea concerns cancer patients. Cancer patients may feel nausea and vomiting. This is frequently linked to chemotherapy side effects. Because of its interaction with serotonin receptors, animal study shows that CBD may aid with nausea. Serotonin is a hormone that influences happiness, mood, and behaviour. However, researchers believe that THC is more likely than CBD to alleviate nausea and vomiting.

 

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